Gender pecularity of the material of reproductive losses

  • I. R. Tkach State Institution «Institute of Hereditary Pathology of the National, Academy of Medical Sciences of Ukraine», Ukraine, 79008, Lviv, M. Lysenko str., 31a https://orcid.org/0000-0002-8370-6935
  • N. L. Huleyuk State Institution «Institute of Hereditary Pathology of the National, Academy of Medical Sciences of Ukraine», Ukraine, 79008, Lviv, M. Lysenko str., 31a https://orcid.org/0000-0001-7697-4117
  • G. M. Bezkorovaina State Institution «Institute of Hereditary Pathology of the National, Academy of Medical Sciences of Ukraine», Ukraine, 79008, Lviv, M. Lysenko str., 31a https://orcid.org/0000-0002-1940-9928
  • N. V. Helner State Institution «Institute of Hereditary Pathology of the National, Academy of Medical Sciences of Ukraine», Ukraine, 79008, Lviv, M. Lysenko str., 31a
  • T. B. Snizhko Ivano-Frankivsk National Medical University, Department of Obstetrics and Gynecology I. D. Lanovogo, Ukraine, 76018, Ivano-Frankivsk, Halytska str., 2
  • O. V. Benko Municipal non-profit enterprise “3rd city clinical hospital of Lviv”, Ukraine, 79000, Lviv, Rusovykh str., 4
DOI: https://doi.org/10.7124/FEEO.v33.1574
Keywords: reproductive loss, karyotype abnormalities, gender ratio

Abstract

Aim. The prognosis of the reproductive function of women with pregnancy loss is complex and partly based on the results of karyotyping of material of reproductive loss. According to the literature, during conception are formed the same number of male and female fetuses, but more boys are born. The purpose of this study was to evaluate the gender ratio and incidence of chromosomal anomalies in the products of conception (POC). Methods. Banding cytogenetic and interphase mFISH with the centromeric probe panel for chromosomes 13, 14, 15, 16, 17, 18, 21, 22, X and Y were used. Results. Were examined 497 cases of material POC. Among all samples, female karyotype was established in 273 cases (54.9 %), and male karyotype in 224 cases (45.1 %). Gender ratio of female to male in the POC, regardless of presence or absence of chromosomal anomalies, is 1.22:1. Conclusions. Depending on presence or absence of chromosomal anomalies in POC, the gender ratio differs: with a normal karyotype, female-to-male ratio is 1.09:1, and with an abnormal karyotype, it is 1.6:1, respectively

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