The impact of genetic and hereditary anomalies on the productivity of agricultural poultry
Abstract
Aim. Aim of the study is to conduct a comprehensive analysis of genetically determined diseases and hereditary abnormalities in farm poultry. Methods. The article is review-based and is based on the analysis, generalisation and systematisation of scientific sources. Results. As a result of the generalisation of scientific data, it has been established that more than 80 hereditary abnormalities have been described in farm poultry, most of which are of mutational origin and are caused by the action of lethal and sublethal genes. The most common defects relate to the development of the skeleton, nervous and immune systems, and metabolism. A significant proportion of these mutations manifest themselves during the embryonic period and lead to the death of embryos or reduced viability of young birds. It has been established that the frequency of genetic abnormalities increases with inbreeding, which justifies the need for genetic control and culling of carriers of undesirable alleles. Studies have also shown that pigmentation disorders and other phenotypic variations can persist in populations under conditions of reduced natural selection. Conclusions. Timely identification of mutations, the use of molecular genetic control methods, and rational selection are key factors in maintaining health, increasing productivity, and improving the economic efficiency of modern poultry farming.
References
Al-Ebshahy E., AboElkhair M., Shehata A., Elgendy E. First report on genetic characterization of egg drop syndrome 1976 virus in Egypt. Brazilian Journal of Microbiology. 2024. Vol. 55 (4). P. 4199–4204. https://doi.org/10.1007/s42770-024-01537-1.
Bulchenko I. O. Subvital mutations of poultry. Bulletin of SNAU. Series “Livestock”. 2012. Vol. 12 (21). P. 93–96.
Charlier C., Li W., Harland C., Littlejohn M., Coppieters W., Creagh F., Davis S., Druet T., Faux P., Guillaume F., Karim L., Keehan M., Kadri N. K., Tamma N., Spelman R., Georges M. NGS-based reverse genetic screen for common embryonic lethal mutations compromising fertility in livestock. Genome Research. 2016. Vol. 26 (10). P. 1333–1341. https://doi.org/10.1101/gr.207076.116.
Chihir’ov V. O., Mazhylovs’ka K. R. Genetic Fundamentals of Animal Breeding: Methodological Guidelines for Conduct-ing Practical Classes for Applicants of the Third (Educational and Scientific) Level of Higher Education for the Degree of Doctor of Philosophy (PhD), Specialty 204 “Technology of Production and Processing of Livestock Products”. Odesa : Odesa State Agrarian University. 2018. 51 p. [in Ukrainian]
Dafallah R. M. Egg Drop Syndrome 76 (EDS76) in birds. EC Microbiology Review. 2023.
Domyan E. T., Hardy J., Wright T., Frazer C., Daniels J., Kirkpatrick J., Wakamatsu K., Hill J. T. SOX10 regulates multiple genes to direct eumelanin versus pheomelanin production in domestic rock pigeon. Pigment Cell and Melanoma Research. 2019. Vol. 32. P. 634–642. https://doi.org/10.1111/pcmr.12778.
Du W., Yang Z., Xiao C., Liu Y., Peng J., Li J., Yang X. Identification of genes involved in regulating the development of feathered feet in chicken embryo. Poultry Science. 2023. Vol. 102 (9). P. 102837. https://doi.org/10.1016/j.psj.2023.102837.
Fan W. L., Ng C. S., Chen C. F., Lu M. Y., Chen Y. H., Liu C. J., Wu S. M., Chen C. K., Chen J. J., Mao C. T., Lai Y. T., Lo W. S., Chang W. H., Li W. H. Genome-wide patterns of genetic variation in two domestic chickens. Genome Biology and Evolution. 2013. Vol. 5 (7). P. 1376–1392. https://doi.org/10.1093/gbe/evt097.
Fulton J. E., McCarron A. M., Mullen A., Ali L., Tarrant K. J. A review of genetic variation underlying chicken phenotypic diversity. Poultry Science. 2025. Vol. 104 (11). P. 105761. https://doi.org/10.1016/j.psj.2025.105761.
Hicks, J. A., Liu, H. C. Centennial Review: Metabolic microRNA – shifting gears in the regulation of metabolic pathways in poultry. Poultry Science. 2021. Vol. 100 (3). Р. 100856. https://doi.org/10.1016/j.psj.2020.11.033.
Himabindu M., Keerthi V., Moni Theresa T., Majumder S. R. Lethal genes in poultry: types, effects and implications. The Science World. 2024. 4 (8). Р. 2795–2798. https://doi.org/10.5281/zenodo.13292692.
Joller S., Bertschinger F., Kump E., Spiri A., von Rotz A. Crossed beaks in a local Swiss chicken breed: Phenotype characterization and prevalence. BMC Veterinary Research. 2018. Vol. 14. Р. 123. https://doi.org/10.1186/s12917-018-1398-z.
Khvostyk V. Hereditary Burden in Poultry of Different Species of the Ukrainian Gene Pool. Scientific Horizons. 2020. 23 (12). Р. 29–35. https://doi.org/10.48077/scihor.23(12).2020.29-35.
Li D., Li Y., Li M., Che T., Tian S., Chen B., Zhou X., Zhang G., Gaur U., Luo M., Tian K., He M., He S., Xu Z., Jin L., Tang Q., Dai Y., Xu H., Hu Y., Zhao X., Yin H., Wang Y., Zhou R., Yang C., Du H., Jiang X., Zhu Q., Li M. Population genomics identifies patterns of genetic diversity and selection in chicken. BMC Genomics. 2019. Vol. 20 (1). P. 263. https://doi.org/10.1186/s12864-019-5622-4.
Liakhovich L. M., Honcharova I. I., Petrenko А. М., Byrka O. V., Zakharyev A. V., Ulyanizka А. Yu., Zhukova І. О., Zhylina V. M., Hrinchenko D. M., Kochevenko O. S. Assessment of the influence of environmental-trophic-biological pa-rameters on the spread and pathomorphological manifestation of mycobacteriosis in zoo birds: a retrospective analysis. Factors in Experimental Evolution of Organisms. 2025. Vol. 37. P. 93–97. https://doi.org/10.7124/FEEO.v37.1753.
McPherson M. C., Delany M. E. Virus and host genomic, molecular, and cellular interactions during Marek’s disease pathogenesis and oncogenesis. Poultry Science. 2016. Vol. 95 (2). P. 412–429. https://doi.org/10.3382/ps/pev369.
Melnyk, A. Y., Sakara, V. S., Vovkotrub, N. V., Kharchenko, A. V., Bilyk, B. P. Metabolic disorders in poultry (review). Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences. 2021. Vol. 23 (103). Р. 125–135. https://doi.org/10.32718/nvlvet10317.
Miller M. M., Taylor R. L. Jr. Brief review of the chicken major histocompatibility complex: the genes, their distribution on chromosome 16, and their contributions to disease resistance. Poultry Science. 2016. Vol. 95 (2). P. 375–392. https://doi.org/10.3382/ps/pev379.
Núñez-León D., Aguirre-Fernández G., Steiner A., Nagashima H., Jensen P., Stoeckli E., Schneider R. A., Sánchez-Villagra M. R. Morphological diversity of integumentary traits in fowl domestication: insights from disparity analysis and embryonic development. Developmental Dynamics. 2019. Vol. 248 (11). P. 1044–1058. https://doi.org/10.1002/dvdy.105.
Ratcliffe M. J. H. Antibodies, immunoglobulin genes and the bursa of Fabricius in chicken B cell development. Developmental and Comparative Immunology. 2006. Vol. 30 (1–2). P. 101–118. https://doi.org/10.1016/j.dci.2005.06.018.
Sultana H., Seo D., Choi N. R., Bhuiyan M. S. A., Lee S. H., Heo K. N., Lee J. H. Identification of polymorphisms in MITF and DCT genes and their associations with plumage colors in Asian duck breeds. Asian-Australasian Journal of An-imal Sciences. 2017. Vol. 31 (2). P. 180. https://doi.org/10.5713/ajas.17.0298.
Wang L., Yang L., Yang S., Jia Z., Cai J., Rong L., Li S. Identification of genes associated with feather color in Liancheng white duck using FST analysis. Animal Genetics. 2022. Vol. 53 (4). P. 518–521. https://doi.org/10.1111/age.13201.
Wang Z., Guo Z., Mou Q., Liu H., Liu D., Tang H., Hou S., Schroyen M., Zhou Z. Unique feather color characteristics and transcriptome analysis of hair follicles in Liancheng White ducks. Poultry Science. 2024. Vol. 103 (7). P. 103794. https://doi.org/10.1016/j.psj.2024.103794.
Yehia N., El-Sayed H. S., Omar S. E., Erfan A., Amer F. Genetic evolution of Marek’s disease virus in vaccinated poultry farms. Veterinary World. 2021. Vol. 14 (6). P. 1512–1519. https://doi.org/10.14202/vetworld.2021.1342-1353.