Comparative analysis of numerical chromosome abnormalities in the material of pregnancy lost before and after the full-scale invasion of the russian federation

  • I. R. Tkach State Institution “Institute of Hereditary Pathology NAMS of Ukraine”, Ukraine, 79008, Lviv, M. Lysenko str., 31a https://orcid.org/0000-0002-8370-6935
  • N. L. Huleiuk State Institution “Institute of Hereditary Pathology NAMS of Ukraine”, Ukraine, 79008, Lviv, M. Lysenko str., 31a https://orcid.org/0000-0001-7697-4117
  • D. V. Zastavna State Institution “Institute of Hereditary Pathology NAMS of Ukraine”, Ukraine, 79008, Lviv, M. Lysenko str., 31a https://orcid.org/0000-0002-3858-7180
  • H. M. Bezkorovaina State Institution “Institute of Hereditary Pathology NAMS of Ukraine”, Ukraine, 79008, Lviv, M. Lysenko str., 31a https://orcid.org/0000-0002-1940-9928
  • N. V. Helner State Institution “Institute of Hereditary Pathology NAMS of Ukraine”, Ukraine, 79008, Lviv, M. Lysenko str., 31a
  • K. O. Sosnina State Institution “Institute of Hereditary Pathology NAMS of Ukraine”, Ukraine, 79008, Lviv, M. Lysenko str., 31a https://orcid.org/0000-0003-4527-2010
  • O. V. Benko Municipal non-profit enterprise Lviv Territorial Medical Association “Clinical Hospital for Planned Treatment, Rehabilitation and Palliative Care”, separate unit "Prince Lev Hospital”, Ukraine, 79019, Lviv, Uzhhorodska str., 1
  • T. B. Snizhko Ivano-Frankivsk National Medical University, Department of Obstetrics and Gynecology I. D. Lanovogo, Ukraine, 76018, Ivano-Frankivsk, Halytska str., 2
DOI: https://doi.org/10.7124/FEEO.v37.1749
Keywords: reproductive loss, chorionic villi, numerical chromosome abnormalities

Abstract

Aim. Approximately 25 % of women have lost at least one pregnancy. The prognosis of reproductive function in women with pregnancy losses is complex and, in many cases, relies on the results of karyotyping of reproductive loss material. We studied the features of the karyotype of material of pregnancy lost before and after the full-scale invasion of the russian federation. Methods. Banding cytogenetic and interphase mFISH with the probe panel for chromosomes 13, 14, 15, 16, 17, 18, 20, 21, 22, X and Y were used. Results. Normal karyotype was established in 1430 cases (63.1 %) analyzed before full-scale invasion (BEFORE) and in 788 cases (59.6 %) – after invasion of russian federation (AFTER). In samples BEFORE, an abnormal karyotype was established in 838 cases (36.9 %) and AFTER – in 534 cases (40.4 %). Conclusions. Numerical chromosome abnormalities, compatible with postnatal human life were more frequently detected in reproductive loss material obtained AFTER (37.1 % vs 34.0 %). Lethal numerical chromosomal abnormalities were more frequently recorded in samples from pregnancies BEFORE (66.0 % vs 62.9 %).

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