Еволюція гена MGMT у приматів: від структури до мобільних генетичних елементів
Анотація
У статті зібрано дані щодо еволюції репаративного гена MGMT у приматів а також простежено за еволюційною долею низки мобільних генетичних елементів (МГЕ). Зроблено висновок, що еволюція гена MGMT у приматів зазнавала різноманітних змін від набуття до втрати екзон/інтронних послідовностей. Що стосується приматоспецифічних МГЕ, то вони мають різну еволюційну історію і шлях – від формування видо/родоспецифічних послідовностей до делеційної деградації і можуть бути компонентами не лише інтронних чи екзонних послідовностей але і складовими екзонів у вигляді фрагментованих послідовностей і не ідентифікуватись як МГЕ.
Посилання
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